Class: Estimand (Estimand)

A precise description of the treatment effect reflecting the clinical question posed by a given clinical trial objective. It summarises at a population level what the outcomes would be in the same patients under different treatment conditions being compared. (ICH E9 R1 Addendum)

URI: https://example.org/usdm/v4/linkml/Estimand

 classDiagram
    class Estimand
    click Estimand href "../../classes/Estimand/"
      Estimand : analysisPopulationId





        Estimand --> "1" AnalysisPopulation : analysisPopulationId
        click AnalysisPopulation href "../../classes/AnalysisPopulation/"



      Estimand : description

      Estimand : extensionAttributes





        Estimand --> "*" ExtensionAttribute : extensionAttributes
        click ExtensionAttribute href "../../classes/ExtensionAttribute/"



      Estimand : id

      Estimand : intercurrentEvents





        Estimand --> "1..*" IntercurrentEvent : intercurrentEvents
        click IntercurrentEvent href "../../classes/IntercurrentEvent/"



      Estimand : interventionIds





        Estimand --> "1..*" StudyIntervention : interventionIds
        click StudyIntervention href "../../classes/StudyIntervention/"



      Estimand : label

      Estimand : name

      Estimand : notes





        Estimand --> "*" CommentAnnotation : notes
        click CommentAnnotation href "../../classes/CommentAnnotation/"



      Estimand : populationSummary

      Estimand : variableOfInterestId





        Estimand --> "1" Endpoint : variableOfInterestId
        click Endpoint href "../../classes/Endpoint/"

Class Properties

Property Value
Class URI usdm:Estimand

Slots

Name Cardinality and Range Description Inheritance
id 1
string		 direct
populationSummary 1
string		 A synopsis of the clinical endpoint of interest within the analysis target study population. direct
name 1
string		 The literal identifier (i.e., distinctive designation) of the estimand. direct
label 0..1
string		 The short descriptive designation for the estimand. direct
description 0..1
string		 A narrative representation of the estimand. direct
notes *
CommentAnnotation		 A brief written record relevant to the study estimand. direct
analysisPopulationId 1
AnalysisPopulation		 A USDM relationship between the Estimand and AnalysisPopulation classes which provides the details associated with an instance of the analysis population used to partially define a study estimand. direct
variableOfInterestId 1
Endpoint		 A USDM relationship between the Estimand and Endpoint classes which provides the details associated with an instance of the variable of interest within a study endpoint used to partially define a study estimand. direct
intercurrentEvents 1..*
IntercurrentEvent		 A USDM relationship between the Estimand and IntercurrentEvent classes which identifies the set of intercurrent events associated with a study estimand. direct
interventionIds 1..*
StudyIntervention		 A USDM relationship between the Estimand and StudyIntervention classes which identifies the set of study interventions associated with the Estimand. direct
extensionAttributes *
ExtensionAttribute		 direct

Usages

used by used in type used
InterventionalStudyDesign estimands range Estimand
ObservationalStudyDesign estimands range Estimand
StudyDesign estimands range Estimand

Identifier and Mapping Information

Schema Source

  • from schema: https://example.org/usdm/v4/linkml

Mappings

Mapping Type Mapped Value
self https://example.org/usdm/v4/linkml/Estimand
native https://example.org/usdm/v4/linkml/Estimand
exact ncit:C188813

Examples

Example: Estimand-02-Standard-Instance

id: estimand-002
name: Composite Estimand for Heart Failure
label: Composite Efficacy Estimand
description: Evaluation of treatment effect considering death as a component of the outcome.
populationSummary: Proportion of subjects alive and without heart failure hospitalization at Month 12.
analysisPopulationId: pop-target-cv-risk
variableOfInterestId: endpoint-composite-outcome
intercurrentEvents:
  - id: ice-002
    text: Death due to any cause prior to the Month 12 assessment.
    strategy: Composite strategy where death is treated as a failure
interventionIds:
  - drug-a-10mg
  - drug-b-standard-care

Example: Estimand-01-Minimal-Data-Instance

id: estimand-001
name: Primary Efficacy - ITT Analysis
populationSummary: Difference in mean change from baseline in HbA1c at Week 52
analysisPopulationId: pop-all-randomized
variableOfInterestId: endpoint-hba1c-52wk
intercurrentEvents:
  - id: ice-001
    text: Discontinuation of investigational medicinal product for any reason.
    strategy: Treatment policy regardless of whether study drug was discontinued
interventionIds:
  - trt-active-drug
  - trt-placebo

Example: Estimand-03-Detailed-Instance

LinkML Source

Direct

name: Estimand
description: A precise description of the treatment effect reflecting the clinical
  question posed by a given clinical trial objective. It summarises at a population
  level what the outcomes would be in the same patients under different treatment
  conditions being compared. (ICH E9 R1 Addendum)
title: Estimand
from_schema: https://example.org/usdm/v4/linkml
exact_mappings:
- ncit:C188813
rank: 1000
attributes:
  id:
    name: id
    from_schema: https://example.org/usdm/v4/linkml
    identifier: true
    domain_of:
    - Abbreviation
    - Activity
    - Address
    - AdministrableProduct
    - AdministrableProductProperty
    - Administration
    - AliasCode
    - AnalysisPopulation
    - AssignedPerson
    - BiomedicalConcept
    - BiomedicalConceptCategory
    - BiomedicalConceptProperty
    - BiomedicalConceptSurrogate
    - BiospecimenRetention
    - Code
    - CommentAnnotation
    - ConditionAssignment
    - DocumentContentReference
    - Duration
    - EligibilityCriterion
    - Encounter
    - Estimand
    - ExtensionAttribute
    - ExtensionClass
    - GeographicScope
    - GovernanceDate
    - Identifier
    - Indication
    - Ingredient
    - Masking
    - MedicalDevice
    - NarrativeContent
    - NarrativeContentItem
    - Organization
    - ParameterMap
    - PersonName
    - PopulationDefinition
    - Procedure
    - ProductOrganizationRole
    - QuantityRange
    - ResponseCode
    - ScheduleTimeline
    - ScheduleTimelineExit
    - ScheduledInstance
    - Strength
    - Study
    - StudyAmendment
    - StudyAmendmentImpact
    - StudyAmendmentReason
    - StudyArm
    - StudyCell
    - StudyChange
    - StudyDefinitionDocument
    - StudyDefinitionDocumentVersion
    - StudyDesign
    - StudyElement
    - StudyEpoch
    - StudyIntervention
    - StudyRole
    - StudySite
    - StudyTitle
    - StudyVersion
    - SubjectEnrollment
    - Substance
    - SyntaxTemplate
    - SyntaxTemplateDictionary
    - Timing
    - TransitionRule
    range: string
    required: true
  populationSummary:
    name: populationSummary
    description: A synopsis of the clinical endpoint of interest within the analysis
      target study population.
    title: Population-Level Summary
    from_schema: https://example.org/usdm/v4/linkml
    exact_mappings:
    - ncit:C188853
    rank: 1000
    domain_of:
    - Estimand
    range: string
    required: true
  name:
    name: name
    description: The literal identifier (i.e., distinctive designation) of the estimand.
    title: Estimand Name
    from_schema: https://example.org/usdm/v4/linkml
    exact_mappings:
    - ncit:C215522
    domain_of:
    - Activity
    - AdministrableProduct
    - AdministrableProductProperty
    - Administration
    - AnalysisPopulation
    - AssignedPerson
    - BiomedicalConcept
    - BiomedicalConceptCategory
    - BiomedicalConceptProperty
    - BiomedicalConceptSurrogate
    - BiospecimenRetention
    - EligibilityCriterion
    - Encounter
    - Estimand
    - GovernanceDate
    - Indication
    - MedicalDevice
    - NarrativeContent
    - NarrativeContentItem
    - Organization
    - PopulationDefinition
    - Procedure
    - ProductOrganizationRole
    - ResponseCode
    - ScheduleTimeline
    - ScheduledInstance
    - Strength
    - Study
    - StudyAmendment
    - StudyArm
    - StudyChange
    - StudyDefinitionDocument
    - StudyDesign
    - StudyElement
    - StudyEpoch
    - StudyIntervention
    - StudyRole
    - StudySite
    - SubjectEnrollment
    - Substance
    - SyntaxTemplate
    - SyntaxTemplateDictionary
    - Timing
    - TransitionRule
    range: string
    required: true
  label:
    name: label
    description: The short descriptive designation for the estimand.
    title: Estimand Label
    from_schema: https://example.org/usdm/v4/linkml
    exact_mappings:
    - ncit:C215524
    domain_of:
    - Activity
    - AdministrableProduct
    - Administration
    - AnalysisPopulation
    - AssignedPerson
    - BiomedicalConcept
    - BiomedicalConceptCategory
    - BiomedicalConceptProperty
    - BiomedicalConceptSurrogate
    - BiospecimenRetention
    - EligibilityCriterion
    - Encounter
    - Estimand
    - GovernanceDate
    - Indication
    - MedicalDevice
    - Organization
    - PopulationDefinition
    - Procedure
    - ProductOrganizationRole
    - ResponseCode
    - ScheduleTimeline
    - ScheduledInstance
    - Strength
    - Study
    - StudyAmendment
    - StudyArm
    - StudyChange
    - StudyDefinitionDocument
    - StudyDesign
    - StudyElement
    - StudyEpoch
    - StudyIntervention
    - StudyRole
    - StudySite
    - SubjectEnrollment
    - Substance
    - SyntaxTemplate
    - SyntaxTemplateDictionary
    - Timing
    - TransitionRule
    range: string
    required: false
  description:
    name: description
    description: A narrative representation of the estimand.
    title: Estimand Description
    from_schema: https://example.org/usdm/v4/linkml
    exact_mappings:
    - ncit:C215523
    domain_of:
    - Activity
    - AdministrableProduct
    - Administration
    - AnalysisPopulation
    - AssignedPerson
    - BiomedicalConceptCategory
    - BiomedicalConceptSurrogate
    - BiospecimenRetention
    - EligibilityCriterion
    - Encounter
    - Estimand
    - GovernanceDate
    - Indication
    - MedicalDevice
    - PopulationDefinition
    - Procedure
    - ProductOrganizationRole
    - ScheduleTimeline
    - ScheduledInstance
    - Strength
    - Study
    - StudyAmendment
    - StudyArm
    - StudyChange
    - StudyDefinitionDocument
    - StudyDesign
    - StudyElement
    - StudyEpoch
    - StudyIntervention
    - StudyRole
    - StudySite
    - SubjectEnrollment
    - Substance
    - SyntaxTemplate
    - SyntaxTemplateDictionary
    - Timing
    - TransitionRule
    range: string
    required: false
  notes:
    name: notes
    description: A brief written record relevant to the study estimand.
    title: Estimand Notes
    from_schema: https://example.org/usdm/v4/linkml
    exact_mappings:
    - ncit:C215521
    domain_of:
    - Abbreviation
    - Activity
    - AdministrableProduct
    - Administration
    - AnalysisPopulation
    - BiomedicalConcept
    - BiomedicalConceptCategory
    - BiomedicalConceptProperty
    - BiomedicalConceptSurrogate
    - EligibilityCriterion
    - Encounter
    - Estimand
    - Indication
    - MedicalDevice
    - PopulationDefinition
    - Procedure
    - StudyAmendment
    - StudyAmendmentImpact
    - StudyArm
    - StudyDefinitionDocument
    - StudyDefinitionDocumentVersion
    - StudyDesign
    - StudyElement
    - StudyEpoch
    - StudyIntervention
    - StudyRole
    - StudyVersion
    - SyntaxTemplate
    range: CommentAnnotation
    required: false
    multivalued: true
    inlined: true
    inlined_as_list: true
  analysisPopulationId:
    name: analysisPopulationId
    description: A USDM relationship between the Estimand and AnalysisPopulation classes
      which provides the details associated with an instance of the analysis population
      used to partially define a study estimand.
    from_schema: https://example.org/usdm/v4/linkml
    rank: 1000
    domain_of:
    - Estimand
    range: AnalysisPopulation
    required: true
    inlined: false
  variableOfInterestId:
    name: variableOfInterestId
    description: A USDM relationship between the Estimand and Endpoint classes which
      provides the details associated with an instance of the variable of interest
      within a study endpoint used to partially define a study estimand.
    from_schema: https://example.org/usdm/v4/linkml
    rank: 1000
    domain_of:
    - Estimand
    range: Endpoint
    required: true
    inlined: false
  intercurrentEvents:
    name: intercurrentEvents
    description: A USDM relationship between the Estimand and IntercurrentEvent classes
      which identifies the set of intercurrent events associated with a study estimand.
    from_schema: https://example.org/usdm/v4/linkml
    rank: 1000
    domain_of:
    - Estimand
    range: IntercurrentEvent
    required: true
    multivalued: true
    inlined: true
    inlined_as_list: true
  interventionIds:
    name: interventionIds
    description: A USDM relationship between the Estimand and StudyIntervention classes
      which identifies the set of study interventions associated with the Estimand.
    from_schema: https://example.org/usdm/v4/linkml
    rank: 1000
    domain_of:
    - Estimand
    range: StudyIntervention
    required: true
    multivalued: true
    inlined: false
  extensionAttributes:
    name: extensionAttributes
    from_schema: https://example.org/usdm/v4/linkml
    domain_of:
    - Abbreviation
    - Activity
    - Address
    - AdministrableProduct
    - AdministrableProductIdentifier
    - AdministrableProductProperty
    - Administration
    - AliasCode
    - AnalysisPopulation
    - AssignedPerson
    - BiomedicalConcept
    - BiomedicalConceptCategory
    - BiomedicalConceptProperty
    - BiomedicalConceptSurrogate
    - BiospecimenRetention
    - Characteristic
    - Code
    - CommentAnnotation
    - Condition
    - ConditionAssignment
    - DocumentContentReference
    - Duration
    - EligibilityCriterion
    - EligibilityCriterionItem
    - Encounter
    - Endpoint
    - Estimand
    - ExtensionAttribute
    - ExtensionClass
    - GeographicScope
    - GovernanceDate
    - Indication
    - Ingredient
    - IntercurrentEvent
    - InterventionalStudyDesign
    - Masking
    - MedicalDevice
    - MedicalDeviceIdentifier
    - NarrativeContent
    - NarrativeContentItem
    - Objective
    - ObservationalStudyDesign
    - Organization
    - ParameterMap
    - PersonName
    - Procedure
    - ProductOrganizationRole
    - Quantity
    - Range
    - ReferenceIdentifier
    - ResponseCode
    - ScheduleTimeline
    - ScheduleTimelineExit
    - ScheduledActivityInstance
    - ScheduledDecisionInstance
    - Strength
    - Study
    - StudyAmendment
    - StudyAmendmentImpact
    - StudyAmendmentReason
    - StudyArm
    - StudyCell
    - StudyChange
    - StudyCohort
    - StudyDefinitionDocument
    - StudyDefinitionDocumentVersion
    - StudyDesignPopulation
    - StudyElement
    - StudyEpoch
    - StudyIdentifier
    - StudyIntervention
    - StudyRole
    - StudySite
    - StudyTitle
    - StudyVersion
    - SubjectEnrollment
    - Substance
    - SyntaxTemplateDictionary
    - Timing
    - TransitionRule
    range: ExtensionAttribute
    required: false
    multivalued: true
    inlined: true
    inlined_as_list: true
class_uri: usdm:Estimand

Induced

name: Estimand
description: A precise description of the treatment effect reflecting the clinical
  question posed by a given clinical trial objective. It summarises at a population
  level what the outcomes would be in the same patients under different treatment
  conditions being compared. (ICH E9 R1 Addendum)
title: Estimand
from_schema: https://example.org/usdm/v4/linkml
exact_mappings:
- ncit:C188813
rank: 1000
attributes:
  id:
    name: id
    from_schema: https://example.org/usdm/v4/linkml
    identifier: true
    alias: id
    owner: Estimand
    domain_of:
    - Abbreviation
    - Activity
    - Address
    - AdministrableProduct
    - AdministrableProductProperty
    - Administration
    - AliasCode
    - AnalysisPopulation
    - AssignedPerson
    - BiomedicalConcept
    - BiomedicalConceptCategory
    - BiomedicalConceptProperty
    - BiomedicalConceptSurrogate
    - BiospecimenRetention
    - Code
    - CommentAnnotation
    - ConditionAssignment
    - DocumentContentReference
    - Duration
    - EligibilityCriterion
    - Encounter
    - Estimand
    - ExtensionAttribute
    - ExtensionClass
    - GeographicScope
    - GovernanceDate
    - Identifier
    - Indication
    - Ingredient
    - Masking
    - MedicalDevice
    - NarrativeContent
    - NarrativeContentItem
    - Organization
    - ParameterMap
    - PersonName
    - PopulationDefinition
    - Procedure
    - ProductOrganizationRole
    - QuantityRange
    - ResponseCode
    - ScheduleTimeline
    - ScheduleTimelineExit
    - ScheduledInstance
    - Strength
    - Study
    - StudyAmendment
    - StudyAmendmentImpact
    - StudyAmendmentReason
    - StudyArm
    - StudyCell
    - StudyChange
    - StudyDefinitionDocument
    - StudyDefinitionDocumentVersion
    - StudyDesign
    - StudyElement
    - StudyEpoch
    - StudyIntervention
    - StudyRole
    - StudySite
    - StudyTitle
    - StudyVersion
    - SubjectEnrollment
    - Substance
    - SyntaxTemplate
    - SyntaxTemplateDictionary
    - Timing
    - TransitionRule
    range: string
    required: true
  populationSummary:
    name: populationSummary
    description: A synopsis of the clinical endpoint of interest within the analysis
      target study population.
    title: Population-Level Summary
    from_schema: https://example.org/usdm/v4/linkml
    exact_mappings:
    - ncit:C188853
    rank: 1000
    alias: populationSummary
    owner: Estimand
    domain_of:
    - Estimand
    range: string
    required: true
  name:
    name: name
    description: The literal identifier (i.e., distinctive designation) of the estimand.
    title: Estimand Name
    from_schema: https://example.org/usdm/v4/linkml
    exact_mappings:
    - ncit:C215522
    alias: name
    owner: Estimand
    domain_of:
    - Activity
    - AdministrableProduct
    - AdministrableProductProperty
    - Administration
    - AnalysisPopulation
    - AssignedPerson
    - BiomedicalConcept
    - BiomedicalConceptCategory
    - BiomedicalConceptProperty
    - BiomedicalConceptSurrogate
    - BiospecimenRetention
    - EligibilityCriterion
    - Encounter
    - Estimand
    - GovernanceDate
    - Indication
    - MedicalDevice
    - NarrativeContent
    - NarrativeContentItem
    - Organization
    - PopulationDefinition
    - Procedure
    - ProductOrganizationRole
    - ResponseCode
    - ScheduleTimeline
    - ScheduledInstance
    - Strength
    - Study
    - StudyAmendment
    - StudyArm
    - StudyChange
    - StudyDefinitionDocument
    - StudyDesign
    - StudyElement
    - StudyEpoch
    - StudyIntervention
    - StudyRole
    - StudySite
    - SubjectEnrollment
    - Substance
    - SyntaxTemplate
    - SyntaxTemplateDictionary
    - Timing
    - TransitionRule
    range: string
    required: true
  label:
    name: label
    description: The short descriptive designation for the estimand.
    title: Estimand Label
    from_schema: https://example.org/usdm/v4/linkml
    exact_mappings:
    - ncit:C215524
    alias: label
    owner: Estimand
    domain_of:
    - Activity
    - AdministrableProduct
    - Administration
    - AnalysisPopulation
    - AssignedPerson
    - BiomedicalConcept
    - BiomedicalConceptCategory
    - BiomedicalConceptProperty
    - BiomedicalConceptSurrogate
    - BiospecimenRetention
    - EligibilityCriterion
    - Encounter
    - Estimand
    - GovernanceDate
    - Indication
    - MedicalDevice
    - Organization
    - PopulationDefinition
    - Procedure
    - ProductOrganizationRole
    - ResponseCode
    - ScheduleTimeline
    - ScheduledInstance
    - Strength
    - Study
    - StudyAmendment
    - StudyArm
    - StudyChange
    - StudyDefinitionDocument
    - StudyDesign
    - StudyElement
    - StudyEpoch
    - StudyIntervention
    - StudyRole
    - StudySite
    - SubjectEnrollment
    - Substance
    - SyntaxTemplate
    - SyntaxTemplateDictionary
    - Timing
    - TransitionRule
    range: string
    required: false
  description:
    name: description
    description: A narrative representation of the estimand.
    title: Estimand Description
    from_schema: https://example.org/usdm/v4/linkml
    exact_mappings:
    - ncit:C215523
    alias: description
    owner: Estimand
    domain_of:
    - Activity
    - AdministrableProduct
    - Administration
    - AnalysisPopulation
    - AssignedPerson
    - BiomedicalConceptCategory
    - BiomedicalConceptSurrogate
    - BiospecimenRetention
    - EligibilityCriterion
    - Encounter
    - Estimand
    - GovernanceDate
    - Indication
    - MedicalDevice
    - PopulationDefinition
    - Procedure
    - ProductOrganizationRole
    - ScheduleTimeline
    - ScheduledInstance
    - Strength
    - Study
    - StudyAmendment
    - StudyArm
    - StudyChange
    - StudyDefinitionDocument
    - StudyDesign
    - StudyElement
    - StudyEpoch
    - StudyIntervention
    - StudyRole
    - StudySite
    - SubjectEnrollment
    - Substance
    - SyntaxTemplate
    - SyntaxTemplateDictionary
    - Timing
    - TransitionRule
    range: string
    required: false
  notes:
    name: notes
    description: A brief written record relevant to the study estimand.
    title: Estimand Notes
    from_schema: https://example.org/usdm/v4/linkml
    exact_mappings:
    - ncit:C215521
    alias: notes
    owner: Estimand
    domain_of:
    - Abbreviation
    - Activity
    - AdministrableProduct
    - Administration
    - AnalysisPopulation
    - BiomedicalConcept
    - BiomedicalConceptCategory
    - BiomedicalConceptProperty
    - BiomedicalConceptSurrogate
    - EligibilityCriterion
    - Encounter
    - Estimand
    - Indication
    - MedicalDevice
    - PopulationDefinition
    - Procedure
    - StudyAmendment
    - StudyAmendmentImpact
    - StudyArm
    - StudyDefinitionDocument
    - StudyDefinitionDocumentVersion
    - StudyDesign
    - StudyElement
    - StudyEpoch
    - StudyIntervention
    - StudyRole
    - StudyVersion
    - SyntaxTemplate
    range: CommentAnnotation
    required: false
    multivalued: true
    inlined: true
    inlined_as_list: true
  analysisPopulationId:
    name: analysisPopulationId
    description: A USDM relationship between the Estimand and AnalysisPopulation classes
      which provides the details associated with an instance of the analysis population
      used to partially define a study estimand.
    from_schema: https://example.org/usdm/v4/linkml
    rank: 1000
    alias: analysisPopulationId
    owner: Estimand
    domain_of:
    - Estimand
    range: AnalysisPopulation
    required: true
    inlined: false
  variableOfInterestId:
    name: variableOfInterestId
    description: A USDM relationship between the Estimand and Endpoint classes which
      provides the details associated with an instance of the variable of interest
      within a study endpoint used to partially define a study estimand.
    from_schema: https://example.org/usdm/v4/linkml
    rank: 1000
    alias: variableOfInterestId
    owner: Estimand
    domain_of:
    - Estimand
    range: Endpoint
    required: true
    inlined: false
  intercurrentEvents:
    name: intercurrentEvents
    description: A USDM relationship between the Estimand and IntercurrentEvent classes
      which identifies the set of intercurrent events associated with a study estimand.
    from_schema: https://example.org/usdm/v4/linkml
    rank: 1000
    alias: intercurrentEvents
    owner: Estimand
    domain_of:
    - Estimand
    range: IntercurrentEvent
    required: true
    multivalued: true
    inlined: true
    inlined_as_list: true
  interventionIds:
    name: interventionIds
    description: A USDM relationship between the Estimand and StudyIntervention classes
      which identifies the set of study interventions associated with the Estimand.
    from_schema: https://example.org/usdm/v4/linkml
    rank: 1000
    alias: interventionIds
    owner: Estimand
    domain_of:
    - Estimand
    range: StudyIntervention
    required: true
    multivalued: true
    inlined: false
  extensionAttributes:
    name: extensionAttributes
    from_schema: https://example.org/usdm/v4/linkml
    alias: extensionAttributes
    owner: Estimand
    domain_of:
    - Abbreviation
    - Activity
    - Address
    - AdministrableProduct
    - AdministrableProductIdentifier
    - AdministrableProductProperty
    - Administration
    - AliasCode
    - AnalysisPopulation
    - AssignedPerson
    - BiomedicalConcept
    - BiomedicalConceptCategory
    - BiomedicalConceptProperty
    - BiomedicalConceptSurrogate
    - BiospecimenRetention
    - Characteristic
    - Code
    - CommentAnnotation
    - Condition
    - ConditionAssignment
    - DocumentContentReference
    - Duration
    - EligibilityCriterion
    - EligibilityCriterionItem
    - Encounter
    - Endpoint
    - Estimand
    - ExtensionAttribute
    - ExtensionClass
    - GeographicScope
    - GovernanceDate
    - Indication
    - Ingredient
    - IntercurrentEvent
    - InterventionalStudyDesign
    - Masking
    - MedicalDevice
    - MedicalDeviceIdentifier
    - NarrativeContent
    - NarrativeContentItem
    - Objective
    - ObservationalStudyDesign
    - Organization
    - ParameterMap
    - PersonName
    - Procedure
    - ProductOrganizationRole
    - Quantity
    - Range
    - ReferenceIdentifier
    - ResponseCode
    - ScheduleTimeline
    - ScheduleTimelineExit
    - ScheduledActivityInstance
    - ScheduledDecisionInstance
    - Strength
    - Study
    - StudyAmendment
    - StudyAmendmentImpact
    - StudyAmendmentReason
    - StudyArm
    - StudyCell
    - StudyChange
    - StudyCohort
    - StudyDefinitionDocument
    - StudyDefinitionDocumentVersion
    - StudyDesignPopulation
    - StudyElement
    - StudyEpoch
    - StudyIdentifier
    - StudyIntervention
    - StudyRole
    - StudySite
    - StudyTitle
    - StudyVersion
    - SubjectEnrollment
    - Substance
    - SyntaxTemplateDictionary
    - Timing
    - TransitionRule
    range: ExtensionAttribute
    required: false
    multivalued: true
    inlined: true
    inlined_as_list: true
class_uri: usdm:Estimand